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7 articles tagged pat.
Quadrupole and membrane-inlet mass spectrometers sit between gas chromatography and inline spectroscopy in the PAT toolkit. The placement and the limits of the technique are settled, even if vendor marketing is loose.
Six vendors that matter for bioreactor monitoring - what each one is good at, what they are not, and the methodology we used to scope the field down from the full process Raman market.
A partial least squares model rarely survives the move to a second instrument unchanged. A working protocol covers transfer set design, the standardisation method, and the acceptance criteria.
Six recent peer-reviewed PAT papers worth a read: lean chemometrics for spectroscopic models, simpler bioprocess Raman regressions, at-line terahertz for crystallinity, and PAT-with-machine-learning past the bioreactor.
ASTM E2363 fixes four terms that engineers and scientists frequently misuse. A short reference for getting placement vocabulary right when scoping a process analytics project.
EMA's March 2026 Q&A on 3D-printed solid oral doses accepts inline NIR and Raman spectroscopy for unit-level rejection, anchoring personalised micro-batches in the QbD and RTRT framework.
Recent peer-reviewed work on time-gated Raman - 512-pixel SPAD line arrays, Fourier-transform variants, and time-resolved use beyond fluorescence rejection - and what process-analytics teams can take from it.