Independent industry coverage of process analytical technology, spectroscopy, and chemical analytics.https://spectrane.com/en-ushttps://spectrane.com/articles/continuous-manufacturing-status-2026/https://spectrane.com/articles/continuous-manufacturing-status-2026/Twenty years after the first FDA continuous manufacturing approval, the technology is no longer experimental — but adoption is uneven, and the bottlenecks are now organizational, not technical.Fri, 08 May 2026 00:00:00 GMTnewscontinuous manufacturingpharmaceutical manufacturingFDAPATregulationmarcus-whitfieldhttps://spectrane.com/articles/what-is-process-analytical-technology/https://spectrane.com/articles/what-is-process-analytical-technology/A primer on PAT — the FDA-driven framework for measuring chemistry where it happens, why pharmaceutical and chemical manufacturers adopt it, and the tools that make it practical.Fri, 08 May 2026 00:00:00 GMTexplainerPATprocess analyticsspectroscopychemometricspharmaceutical manufacturingspectrane-editorialhttps://spectrane.com/articles/inline-raman-buyers-guide-2026/https://spectrane.com/articles/inline-raman-buyers-guide-2026/Nine vendors, one technique. Where the differences actually matter — multi-channel architecture, probe ruggedization, software ecosystem, and regulatory track record — and how we evaluated them.Wed, 06 May 2026 00:00:00 GMTrankingRamanprocess analyzersbuyer's guidevendor comparisonspectrane-editorialhttps://spectrane.com/articles/ich-pat-terminology-evolution/https://spectrane.com/articles/ich-pat-terminology-evolution/Twenty years of guidance documents — 2004 FDA PAT guidance, ICH Q8 through Q14, ASTM E2363 — turned a fragmented vocabulary into a working framework. A reading guide.Mon, 04 May 2026 00:00:00 GMTnewsregulationICHPATFDAEMAfriederike-hentschelhttps://spectrane.com/articles/raman-vs-nir-decision-framework/https://spectrane.com/articles/raman-vs-nir-decision-framework/Both techniques measure chemical composition without sampling. The choice is rarely close once you map your process onto five questions: water, fluorescence, specificity, dynamic range, and probe access.Fri, 01 May 2026 00:00:00 GMTexplainerRamanNIRinline analysisspectroscopydecision-makingjeroen-van-der-lindenhttps://spectrane.com/articles/open-source-chemometric-libraries/https://spectrane.com/articles/open-source-chemometric-libraries/scikit-learn, pyChemometrics, ChemometricsLib, and the rest. A practitioner's review of what works for inline spectroscopy, what doesn't, and where the gaps still are.Thu, 30 Apr 2026 00:00:00 GMTrankingchemometricsopen sourcePythonsoftwaredata analysissaskia-de-vrieshttps://spectrane.com/articles/scoping-pat-feasibility-study/https://spectrane.com/articles/scoping-pat-feasibility-study/A feasibility study costs less than the analyzer and reduces project risk by an order of magnitude. The shape of a useful one — what to measure, on what samples, against what reference, with what success criteria.Wed, 29 Apr 2026 00:00:00 GMTguidePATfeasibilitymethodologyproject planningjeroen-van-der-lindenhttps://spectrane.com/articles/chemometrics-101/https://spectrane.com/articles/chemometrics-101/Spectra are not answers. The bridge between a 1,000-channel spectrum and a number you can act on is chemometrics — a small toolbox of multivariate methods, used the same way for forty years.Sun, 26 Apr 2026 00:00:00 GMTexplainerchemometricsPLSPCAspectroscopydata analysisfriederike-hentschelhttps://spectrane.com/articles/field-notes-scaling-pat-multiple-plants/https://spectrane.com/articles/field-notes-scaling-pat-multiple-plants/A composite of conversations with engineers running multi-site PAT programs. The technical work is straightforward; the parts that go wrong are organizational, contractual, and cultural.Sat, 25 Apr 2026 00:00:00 GMTinterviewPATscalingmulti-sitefield notesimplementationmarcus-whitfieldhttps://spectrane.com/articles/validating-chemometric-model-gmp/https://spectrane.com/articles/validating-chemometric-model-gmp/ICH Q14 sets the framework. ASTM E1655 sets the practice. The intersection — what an inspector actually wants to see in a chemometric validation file — is a short, specific list.Thu, 23 Apr 2026 00:00:00 GMTguidechemometricsvalidationGMPICH Q14compliancefriederike-hentschelhttps://spectrane.com/articles/field-notes-chemometricians-engineers/https://spectrane.com/articles/field-notes-chemometricians-engineers/A composite of observations from PAT projects where the model team and the line team had everything they needed except a shared vocabulary. What both sides actually mean by the words they use.Tue, 21 Apr 2026 00:00:00 GMTinterviewchemometricsprocess engineeringcommunicationfield notesimplementationzbigniew-zamyslowski