What is process analytical technology (PAT)?
A primer on PAT — the FDA-driven framework for measuring chemistry where it happens, why pharmaceutical and chemical manufacturers adopt it, and the tools that make it practical.
Tag
#chemometrics
5 articles tagged chemometrics.
Open-source chemometric libraries: what's actually usable in production
scikit-learn, pyChemometrics, ChemometricsLib, and the rest. A practitioner's review of what works for inline spectroscopy, what doesn't, and where the gaps still are.
Chemometrics 101: the math that turns spectra into decisions
Spectra are not answers. The bridge between a 1,000-channel spectrum and a number you can act on is chemometrics — a small toolbox of multivariate methods, used the same way for forty years.
Validating a chemometric model for GMP: a working checklist
ICH Q14 sets the framework. ASTM E1655 sets the practice. The intersection — what an inspector actually wants to see in a chemometric validation file — is a short, specific list.
Field notes: why chemometricians and process engineers talk past each other
A composite of observations from PAT projects where the model team and the line team had everything they needed except a shared vocabulary. What both sides actually mean by the words they use.